Effect of vaccination with refined components of the organism on infection of mice with Mycobacterium leprae.

نویسندگان

  • Maeya Ngamying
  • Pathom Sawanpanyalert
  • Raywadee Butraporn
  • Junjira Nikasri
  • Sang-Nae Cho
  • Louis Levy
  • Patrick J Brennan
چکیده

Only native products of Mycobacterium leprae, whether cell wall, cytosol, or membrane derived, can confer protective immunity against challenge in the mouse footpad. Previously, recombinant proteins were shown to be ineffective. The cell wall skeleton-the mycolyl-arabinogalactan-peptidoglycan complex-devoid of proteins is not protective.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Detection of Non-Tuberculosis Mycobacteria Infection due to Mycobacterium leprae and Mycobacterium kansasii in Patients Suspected of Tuberculosis in Isfahan, Iran

Several reports have indicated that infection with Non-Tuberculosis Mycobacteria (NTM) is increasing worldwide.Therefore,monitoring species causing micobacterial infection in any region is of great importance. This study was going to detect, differentiate, and identify pathogenic mycobacteria in primary clinical samples. Eighty samples collected from tuberculosis suspected patients in Isfahan/I...

متن کامل

A RAPID AND SIMPLE METHOD OF DNA EXTRACTION FROM CLINICAL SPECIMENS CONTAINING MYCOBACTERIUM LEPRAE FOR PCR ASSAYS

We describe a rapid, simple, and reliable procedure for routine isolation of Mycobacterium leprae DNA from slit-skin swab specimens. This one-step DNA extraction method is based on the utilization of ChelexR 100, a chelating ion exchange resin. Slit-skin swab specimens from seven untreated leprosy patients at Baba Baghi Leprosy Hospital in Iran were processed by this procedure. The polymer...

متن کامل

Protection against virulent Mycobacterium avium infection following DNA vaccination with the 35-kilodalton antigen is accompanied by induction of gamma interferon-secreting CD4(+) T cells.

Mycobacterium avium is an opportunistic pathogen that primarily infects immunocompromised individuals, although the frequency of M. avium infection is also increasing in the immunocompetent population. The antigen repertoire of M. avium varies from that of Mycobacterium tuberculosis, with the immunodominant 35-kDa protein being present in M. avium and Mycobacterium leprae but not in members of ...

متن کامل

Specific and nonspecific resistance in mice immunized with irradiated Myobacterium leprae.

Following subcutaneous inoculation of irradiated Mycobacterium leprae (I-ML) into the left hind footpad of mice, there was increased resistance to Listeria monocytogenes, indicative of macrophage activation, at the immunization site. In spite of the high level of localized macrophage activation which was proportioned to the immunizing dose of I-ML, no such activity could be demonstrated systemi...

متن کامل

Immunomodulating Effect of Cyclophosphamide on the Mice Infected with Candida albicans

Background & Objectives: Cyclophosphamide is an alkylating agent that stops the replication of DNA, which is used to treat various types of cancer and some autoimmune disorders. This study was aimed at then evaluating the immunomodulating effect of cyclophosphamide (Cy) on the immune system of vaccinated and non-vaccinated mice.Materials & Methods: The  study was performed on three groups of mi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Infection and immunity

دوره 71 3  شماره 

صفحات  -

تاریخ انتشار 2003